| Name | Lycorine hydrochloride | ||
| PubChem CID | 164943 | ||
| Molecular Weight | 323.77g/mol | ||
| Formula | C₁₆H₁₈ClNO₄ | ||
| SMILES | C1CN2CC3=CC4=C(C=C3C5C2C1=CC(C5O)O)OCO4.Cl | ||
| InChI | 1S/C16H17NO4.ClH/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19;/h3-5,11,14-16,18-19H,1-2,6-7H2;1H/t11-,14-,15+,16+;/m0./s1 | ||
| InChIKey | VUVNTYCHKZBOMV-NVJKKXITSA-N | ||
| CAS Number | 2188-68-3 | ||
| ChEMBL ID | CHEMBL2092590 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
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2D
MOL
3D
MOL
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| Chineses Pinyin | ShiSuan | ||
| Use Part | Bulb | ||
| Habitat | JiangSu, ZheJiang, AnHui, FuJian, JiangXi, ShanDong, ShangHai, HeNan, HuNan, HuBei, GuangDong, GuangXi, HaiNan, SiChuan, GuiZhou, YunNan, XiZang, ChongQing, ShanXi, HeNan, JiangSu, ZheJiang | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Asparagales
-->Family: Amaryllidaceae
-->Genus: Lycoris
-->Species: Lycoris radiata
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| Pair Name | Lycorine hydrochloride, Anti-CTLA-4 | |||
| Partner Name | Anti-CTLA-4 | |||
| Disease Info | [ICD-11: 2C90.0] | Renal cell carcinoma | Investigative | |
| Biological Phenomena | Inhibition-->Immune checkpoint | |||
| Gene Regulation | Down-regulation | Expression | CCND1 | hsa595 |
| Down-regulation | Expression | CCND3 | hsa896 | |
| Down-regulation | Expression | CDK2 | hsa1017 | |
| In Vitro Model | Caki-1 | Clear cell renal cell carcinoma | Homo sapiens (Human) | CVCL_0234 |
| ACHN | Papillary renal cell carcinoma | Homo sapiens (Human) | CVCL_1067 | |
| KPK1 | Renal cell carcinoma | Homo sapiens (Human) | CVCL_F947 | |
| RenCa | Mouse kidney carcinoma | Mus musculus (Mouse) | CVCL_2174 | |
| In Vivo Model | Renca-Luc cells were inoculated into the sub-renal capsule kidney (3×10⁵ cells in 50 μl PBS) and tail vein (2×10⁵ cells in 30 μl PBS) of C57BL/6 mice to produce an orthotopic tumor and metastatic lung tumors. | |||
| Result | Synergistic effects of the immune checkpoint inhibitor CTLA-4 combined with the growth inhibitor lycorine in a mouse model of renal cell carcinoma | |||
